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Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Co-processing of small molecule excipients with polymers to improve functionality.

Prashantkumar K Parmar1, Srilaxmi G Rao1, Arvind K Bansal1

  • 1Solid State Pharmaceutics Lab, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India.

Expert Opinion on Drug Delivery
|January 8, 2021
PubMed
Summary
This summary is machine-generated.

Co-processing small molecule excipients (SMEs) with polymers enhances their functionality. This technique creates multi-functional excipients, overcoming limitations of individual components for improved drug formulation.

Keywords:
Small molecule excipientsco-processed excipientsco-processingfunctionalitypolymers

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Area of Science:

  • Pharmaceutical excipient science
  • Polymer science in drug delivery

Background:

  • Small molecule excipients (SMEs) often lack optimal properties like flow and compressibility.
  • Polymers are utilized in various pharmaceutical applications, including drug release modification and packaging.

Purpose of the Study:

  • To review the application of co-processing SMEs with polymers to enhance functionality.
  • To discuss the properties of polymers suitable for co-processing.
  • To explore the advantages, methods, and commercial aspects of co-processed excipients.

Main Methods:

  • Review of literature on co-processing techniques involving polymers and SMEs.
  • Analysis of physicochemical and mechanical properties of polymers for co-processing.
  • Examination of functionality enhancement and mechanistic insights.

Main Results:

  • Co-processing SMEs with polymers creates synergistic effects, yielding multi-functional excipients.
  • This approach can overcome limitations of individual excipients, particularly for poorly compactable drugs.
  • Novel co-processed excipients can lead to intellectual property generation.

Conclusions:

  • Co-processing with polymers is a valuable technique to improve SME functionality.
  • The synergy between SMEs and polymers results in advanced excipients with desirable properties.
  • This strategy offers potential for developing innovative drug formulations and securing intellectual property.