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Updated: Aug 29, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Effect of contact letter on control response rates in cancer studies
S D Walter1, L D Marrett, N Mishkel
1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Abstract:
Our analysis of response rates for community controls approached in a retrospective study of melanoma indicates that there was an 11 per cent improvement in response rate when the contact letter was changed from inviting participation in a "healthy study" with no mention of cancer to a format which explicitly explained that the study concerned cancer. This improvement was observed for all age-sex groups except younger males. The result suggest that higher response rates may be achieved in studies of cancer if fuller disclosure of the study purposes is made.
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