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Acquired cystic kidney disease: occurrence in patients on chronic peritoneal dialysis
L D Truong1, M Q Ansari, S J Ansari
1Department of Pathology, Baylor College of Medicine, Houston, TX 77030.
Insights
Acquired cystic kidney disease (ACKD) can occur in patients on peritoneal dialysis, not just hemodialysis. The study suggests ACKD
Area of Science:
- Nephrology
- Urology
Background:
- Acquired cystic kidney disease (ACKD) is a known complication in patients undergoing long-term hemodialysis.
- Cases of ACKD in patients on continuous ambulatory peritoneal dialysis (CAPD) are rare, with only six previously reported.
- This study investigates ACKD development in patients on CAPD.
Observation:
- Two cases of ACKD in patients on CAPD are presented.
- The patients' clinical data and kidney pathology were analyzed.
Findings:
- ACKD can develop irrespective of the dialysis modality (hemodialysis or CAPD).
- The morphological characteristics of ACKD in the reported CAPD patients were similar to those observed in hemodialysis patients.
- Hemodialysis is not an essential prerequisite for the development of ACKD.
Implications:
- These findings challenge the traditional association of ACKD solely with hemodialysis.
- The study suggests that the underlying factors contributing to ACKD may be related to kidney disease itself rather than the dialysis method.
- Further research is warranted to elucidate the pathogenesis of ACKD in dialysis patients.
Abstract:
Acquired cystic kidney disease (ACKD) is a well-known complication of long-term hemodialysis. To the best of our knowledge, only six patients on continuous ambulatory peritoneal dialysis have been reported to develop this disease. We herein report two such cases, and concluded that the morphology of ACKD seems to be independent of the type of dialysis and that hemodialysis is not necessary for the development of ACKD.