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Updated: Nov 22, 2025

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
[Pathology of heart transplantation: Where are we now?]
Marion Rabant1, Guillaume Coutance2, Pierre Isnard1
1Service d'anatomie et cytologie pathologiques, hôpital Necker-Enfant malades, 149, rue de Sèvres, 75015 Paris, France; Université de Paris, Paris, France; Inserm U1151, hôpital Necker-Enfant malades, Paris, France.
Abstract:
Pathology is still the gold standard for the diagnosis of rejection in heart transplantation. During the last decade, molecular pathology has emerged as a powerful tool for the understanding of the processes implicated in allograft rejection. Transcriptomic analysis of the allograft may also help the pathologist for diagnosis and accurate classification of rejection. This review will describe the recent advances and perspectives of molecular pathology in the field of heart transplantation.
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