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Updated: Nov 22, 2025
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Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
Published on: September 7, 2021
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Chromosomal Analysis of Pre-implantation Embryos: Its Place in Current IVF Practice
Sadhana K Desai1,2,3, Vijay S Mangoli2,3
1Prof. Emirates Obstetrics & Gynaecology, Bombay Hospital Postgraduate Institute of Medical Science, Mumbai, India.
Journal of Obstetrics and Gynaecology of India
|January 8, 2021
Summary
Preimplantation genetic testing (PGT) analyzes embryos for chromosomal abnormalities before in vitro fertilization (IVF) transfer. This improves pregnancy rates per transfer by avoiding aneuploid embryo implantation.
Area of Science:
- Reproductive medicine
- Human genetics
- Embryology
Background:
- Advances in molecular genetics enable chromosomal aberration detection in preimplantation embryos.
- Accurate characterization of human genome variation is now possible.
- Indications for preimplantation embryo chromosomal analysis include heritable disorders and recurrent miscarriages.
Purpose of the Study:
- To summarize current indications for preimplantation embryo chromosomal analysis.
- To review the role of preimplantation genetic testing in IVF treatment.
Main Methods:
- Review of current clinical applications of molecular genetics in assisted reproductive technology (ART).
- Discussion of embryo biopsy techniques and their limitations.
Main Results:
- Preimplantation genetic testing (PGT) is widely used in IVF to diagnose euploid embryos.
- Eliminating aneuploid embryo transfer enhances pregnancy rates per embryo transfer.
- PGT shortens conception time in IVF treatment cycles.
Conclusions:
- Current embryo biopsy techniques have associated advantages and shortcomings.
- PGT-A is increasingly used in routine IVF, but risks of euploid embryo loss exist.
- Careful consideration of PGT-A's role in IVF is necessary due to potential biopsy-related risks.
