Indian Society for Assisted Reproduction Consensus Guidelines on Preimplantation Genetic Testing in In vitro...

Area of Science:

• Reproductive Medicine
• Clinical Genetics
• Embryology

Background:

• Pre-Implantation Genetic Testing (PGT) is utilized in India to identify euploid embryos for transfer, aiding couples in achieving healthy pregnancies.
• International debates persist regarding the offering and validation of PGT, with a lack of consensus on its widespread application.

Purpose of the Study:

• To establish good practice guidelines for Pre-implantation Genetic Testing (PGT) specifically tailored for application in India.
• To address the need for standardized protocols in PGT and embryo biopsy practices within the Indian context.

Main Methods:

• A 2-day consensus meeting convened experts from clinical, embryological, and genetic fields.
• Information was collated through surveys, scientific evidence review, and expert presentations on pre-defined topics related to PGT and embryo biopsy.

Main Results:

• The report details terminologies, requirements, qualifications, and recommendations for PGT for Aneuploidy (PGT-A), monogenic diseases (PGT-M), and reproductive aneuploidies (PGT-SR).
• It includes quality management aspects and lays down good practice points for laboratories performing PGT.

Conclusions:

• The guidelines are derived from expert opinion and may be updated as more data becomes available.
• These recommendations are intended to help standardize PGT services across India and enhance clinical outcomes.