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Delayed pressure urticaria histologically resembles cutaneous late-phase reactions
Y A Mekori1, B S Dobozin, A L Schocket
1Allergy-Immunology Unit, Meir Hospital, Kfar-Saba, Israel.
Archives of Dermatology
|February 1, 1988
Summary
Delayed pressure urticaria (DPU) lesions are histologically similar to late cutaneous reactions (LCR). Both DPU and LCR show increased dermal infiltrating cells compared to normal skin, indicating a shared inflammatory pathway in these urticarial conditions.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Delayed pressure urticaria (DPU) is a distinct urticarial condition characterized by a late-phase reaction to pressure.
- Late cutaneous reactions (LCR) are observed following intradermal injections or skin testing, suggesting a common hypersensitivity mechanism.
Purpose of the Study:
- To histologically compare pressure-induced lesions in DPU with LCR induced by compound 48/80.
- To investigate the cellular infiltrate and fibrin deposition in DPU lesions and LCR.
Main Methods:
- Skin biopsy specimens were obtained from patients with DPU and chronic urticaria (CU), and from control subjects.
- Histologic analysis included Giemsa staining and immunofluorescence of 1-micron sections.
- Cell counts (total and differential) and fibrin deposition were assessed in pressure lesions, LCR sites, and normal skin.
Main Results:
- Interstitial fibrin deposits were observed in both LCR and DPU lesions via immunofluorescence.
- Both LCR and DPU sites showed significantly higher numbers of infiltrating dermal cells compared to normal skin.
- The cellular infiltrate in DPU and LCR was predominantly mononuclear and perivascular.
Conclusions:
- Lesions in delayed pressure urticaria (DPU) are morphologically similar to classic late cutaneous reactions (LCR).
- The findings suggest a shared inflammatory process in DPU and LCR, characterized by increased mononuclear cell infiltration and fibrin deposition.