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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
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Variability in Cardiac Biomarkers during Hemodialysis: A Prospective Cohort Study.
David Collister1,2,3, Andrea Mazzetti1, Anuja Bhalerao1
1Division of Nephrology, Department of Medicine, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Clinical Chemistry
|January 8, 2021
Summary
Hemodialysis significantly alters cardiac biomarker levels, with ultrafiltration increasing high sensitivity troponin I (hs-TnI), galectin-3 (gal-3), and heart-type fatty acid binding protein (hFABP). Treatment time also impacts these markers.
Area of Science:
- Cardiology
- Nephrology
- Biomarker Research
Background:
- The impact of hemodialysis on cardiac biomarkers remains incompletely understood.
- Intradialytic variability of key cardiac biomarkers needs thorough investigation.
Purpose of the Study:
- To evaluate the degree and causes of intradialytic variability for high sensitivity troponin I (hs-TnI), galectin-3 (gal-3), and heart-type fatty acid binding protein (hFABP).
Main Methods:
- Prospective measurement of hs-TnI, gal-3, and hFABP pre- and post-dialysis over 6 months in 178 hemodialysis patients.
- Multilevel linear regression models were used to assess biomarker concentration changes during hemodialysis.
Main Results:
- Ultrafiltration significantly increased hs-TnI, gal-3, and hFABP concentrations.
- Galectin-3 and hFABP decreased with increased blood volume processed and treatment time.
- hs-TnI decreased with hemodialysis treatment time, but was increased by ultrafiltration.
Conclusions:
- Ultrafiltration volume and hemodialysis treatment duration are critical factors influencing cardiac biomarker concentrations.
- These factors must be considered for accurate interpretation of hs-TnI, gal-3, and hFABP measurements in hemodialysis patients.
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