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Self-Assembled pH and Redox Dual Responsive Carboxymethylcellulose-Based Polymeric Nanoparticles for Efficient
Ke-Feng Liu1, Yan-Xue Liu1, Chun-Xiao Li1
1Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, People's Republic of China.
ACS Biomaterials Science & Engineering
|January 9, 2021
Summary
New dual-responsive nanoparticles (CTPP/HCPT) offer enhanced cancer therapy by releasing drugs in response to tumor microenvironments. These biocompatible nanoparticles effectively suppress tumor growth with reduced side effects.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Growing demand for biocompatible polymeric nanoparticles with controlled drug release profiles.
- Need for advanced drug delivery systems to overcome limitations of conventional cancer therapies.
Purpose of the Study:
- To develop and characterize novel carboxymethylcellulose-based dual-responsive polymeric nanoparticles (CTPP/HCPT) for efficient drug codelivery.
- To evaluate the pH and redox-responsive drug release behavior of CTPP/HCPT nanoparticles.
- To assess the in vitro and in vivo efficacy and safety of CTPP/HCPT nanoparticles in cancer treatment.
Main Methods:
- Synthesis and characterization of carboxymethyl cellulose-dithiopropionate hydrazide-8arm-polyethylene glycol-pterostilbene/10-hydroxy camptothecin (CTPP/HCPT) nanoparticles.
- Evaluation of nanoparticle size, drug loading capacity, and biocompatibility.
- In vitro drug release studies under varying pH and redox conditions.
- In vitro and in vivo studies to assess anticancer activity and adverse effects.
Main Results:
- Well-dispersed CTPP/HCPT nanoparticles (approx. 144 nm) with high drug loading capacity and good biocompatibility were successfully prepared.
- Rapid drug release was observed in response to acidic or reductive stimuli, with significantly higher release (74.8%) in a weakly acidic/reductive environment compared to physiological conditions (19.6%).
- In vitro and in vivo studies demonstrated potent cancer cell killing, tumor growth suppression, and lower adverse effects.
Conclusions:
- CTPP/HCPT nanoparticles represent a promising dual-responsive drug delivery system for cancer therapy.
- The dual-responsive nature allows for targeted drug release within the tumor microenvironment, enhancing efficacy and reducing systemic toxicity.
- These nanoparticles show significant potential as effective candidates for advanced cancer treatment strategies.
