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Updated: Nov 22, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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The Role of cis- and trans-Acting RNA Regulatory Elements in Leukemia

Irina A Elcheva1, Vladimir S Spiegelman1

  • 1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, P.O. Box 850, MC H085, 500 University Drive, Hershey, PA 17033-0850, USA.

Cancers
|January 9, 2021
PubMed

Insights

RNA networks are crucial for cell function and cancer development. Targeting specific RNA elements offers new diagnostic and therapeutic strategies for leukemia.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • RNA molecules contribute to cellular diversity and integrate genetic and metabolic pathways.
  • Dysregulated RNA networks are characteristic of cancer, with aberrant expression of long non-coding RNA (lncRNA), micro RNA (miRNA), and circular RNA (circRNA) observed in tumors.
  • Mutations in regulatory cis-acting RNA motifs serve as biomarkers for cancer development and progression.

Purpose of the Study:

  • To review the current progress in targeting RNA elements for leukemia.
  • To discuss the challenges and future prospects of using RNA-based biomarkers and therapeutics for leukemia.

Main Methods:

  • Literature review of studies on RNA elements in cancer.
  • Analysis of aberrant RNA expression in leukemia.
  • Investigation of cis-acting and trans-acting RNA motifs in leukemia pathogenesis.

Main Results:

  • Aberrant expression of lncRNA, miRNA, and circRNA is a hallmark of leukemia.
  • Mutations in cis-acting RNA motifs are recurrent and associated with disease progression.
  • RNA elements present potential as diagnostic biomarkers and therapeutic targets.

Conclusions:

  • Targeting cis-acting and trans-acting RNA elements holds promise for novel leukemia diagnostics and therapeutics.
  • Further research is needed to overcome challenges in RNA-based treatment strategies for leukemia.
Keywords:
RNAleukemiapediatric leukemia

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