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Updated: Nov 22, 2025

Rapid Isolation of the Mitoribosome from HEK Cells
Published on: October 4, 2018
Role of GTPases in Driving Mitoribosome Assembly
Priyanka Maiti1, Elena Lavdovskaia2, Antoni Barrientos3
1Department of Neurology, University of Miami Miller School of Medicine, 1420 NW 9th Avenue, Neurology Research Building # 103B, Miami, FL 33136, USA.
Abstract:
Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we review recent progress in our understanding of mitoribosome assembly GTPases. We describe their shared and specific features and mechanisms of action, compare them with their bacterial counterparts, and discuss their possible roles in the assembly of small or large mitoribosomal subunits and the formation of the monosome by establishing quality-control checkpoints during these processes. Furthermore, following the recent unification of the nomenclature for the mitoribosomal proteins, we also propose a unified nomenclature for mitoribosome assembly GTPases.
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