Related Experiment Video

Updated: Nov 22, 2025

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.3K

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lacy E Lowry1,2, Maryanne C Herzig2, Barbara A Christy3,4

  • 1Department of Internal Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.

Stem Cell Reviews and Reports
|January 9, 2021
PubMed

Insights

Cellular therapies show promise for treating traumatic injuries by aiding tissue repair and restoring organ function. Research is exploring these innovative treatments for both military and civilian applications.

Area of Science:

  • Regenerative Medicine
  • Trauma Care
  • Cellular Therapeutics

Background:

  • Traumatic injuries represent a significant cause of mortality and morbidity globally.
  • Current treatments for traumatic injuries often require novel strategies due to injury complexity.
  • Cellular therapies offer a promising avenue for addressing tissue damage and dysfunction.

Purpose of the Study:

  • To review the current status of cellular therapies for traumatic injury treatment.
  • To discuss the future potential and directions of cell-based treatments in trauma care.
  • To highlight ongoing research and clinical trials in this therapeutic area.

Main Methods:

  • Review of published scientific literature on cellular therapies for traumatic injuries.
  • Analysis of data from preclinical studies and ongoing clinical trials.
  • Discussion of the mechanisms by which cellular therapeutics may benefit trauma patients.

Main Results:

  • Cellular therapies demonstrate potential in complementing existing treatments for traumatic injuries.
  • These therapies may restore organ function compromised by tissue disruption, hypoxia, or inflammation.
  • A range of cell-based pharmaceuticals are under investigation in various stages of research.

Conclusions:

  • Cellular therapies hold significant promise for optimizing outcomes in traumatic injury management.
  • Further research and clinical trials are essential to fully realize the potential of these treatments.
  • Individualized cellular therapeutic strategies may be key to advancing trauma care.
Keywords:
Cell therapyTrauma

More Related Videos

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model10:03

Tracking Superparamagnetic Iron Oxide-labeled Mesenchymal Stem Cells using MRI after Intranasal Delivery in a Traumatic Brain Injury Murine Model

Published on: November 21, 2019

7.9K
Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.8K

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.4K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.3K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.7K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.0K