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Altered Vascular Extracellular Matrix in the Pathogenesis of Atherosclerosis

Rohit Mohindra1, Devendra K Agrawal1, Finosh G Thankam2

  • 1Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766-1854, USA.

Journal of Cardiovascular Translational Research
|January 9, 2021
PubMed

Insights

Cardiovascular disease, particularly atherosclerosis, involves changes in the blood vessel

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Pathology

Background:

  • Cardiovascular disease poses a significant global health challenge.
  • Atherosclerosis, a primary cause of coronary artery disease, involves complex vascular changes.
  • Extracellular matrix (ECM) homeostasis is crucial in vascular health.

Purpose of the Study:

  • To review the role of the extracellular matrix (ECM) in atherosclerosis pathogenesis.
  • To discuss ECM components and their alterations in blood vessels.
  • To explore how ECM changes influence cellular behavior and disease progression.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of ECM's role in vascular pathophysiology.
  • Focus on cellular phenotypes within blood vessel structures.

Main Results:

  • ECM alterations significantly impact inflammatory responses.
  • Changes in ECM affect vascular smooth muscle cell proliferation and migration.
  • ECM modifications contribute to neointimal formation and vascular fibrosis in atherosclerosis.

Conclusions:

  • Understanding ECM's role in atherosclerosis pathogenesis is key.
  • Targeting ECM alterations presents potential therapeutic strategies.
  • Mitigating ECM's detrimental effects could reduce the burden of atherosclerosis.

Keywords:
AtherosclerosisECM homeostasisElastokinesMatrikinesNeointimal hyperplasia

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