Gender is associated with long-term mortality after cerebellopontine angle tumor resection

Gender can contribute to adverse patient outcomes through social and biological factors. It is important to assess the effects of gender on long-term patient outcomes after care has already been accessed, in order to improve quality of care and mitigate healthcare disparities.

277 consecutive patients undergoing cerebellopontine angle tumor resection over a six-year period (June 09, 2013 - April 29, 2019) at a university health system were retrospectively evaluated. Outcomes included 90-day emergency department (ED) visit, readmission, reoperation and mortality following resection. Male and female patients in the whole population were analyzed by logistic regression. Thereafter, Coarsened Exact Matching was used to match female and male on important demographic factors, including history of prior surgery, median household income, and Charlson Comorbidity Index (CCI) score, among others. Regression was carried out in the matched population, with significance set at a p-value < 0.05.

In the matched population analysis, males were significantly more likely to experience mortality during the length of follow-up (p = 0.03) but not within 90-days of resection. There were no significant differences in 90-day mortality or reoperation during the length of follow-up in either the matched or pre-matched populations. No significant differences were found in any of the 90-day morbidity outcomes in either the matched or pre-matched populations.

Gender may predict long-term outcomes in patients following CPA tumor resection. It is possible that gender also contributes to outcome disparities in other neurosurgical procedures, which future studies should evaluate.