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Updated: Nov 22, 2025
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
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[Serological and molecular study of a novel B(A) allele with multiple missense mutations]
Bin Han1, Shaoqiang Zhang, Yuli Zhu
1Qingdao Blood Center, Shandong 266071, China. qdxzxxs@163.com.
Objective:
To explore the molecular basis for an individual suspected as AwB subtype through DNA sequencing.
Methods:
ABO serology was carried out with the standard tube method. To identify the ABO gene haplotype, the amplicons of exon 7 were cloned and sequenced.
Results:
Serological results showed that the forward typing was AwB and the reverse typing was B. Sequencing analysis revealed that the sample has contained an O01 allele in addition with c.297A>G, c.657C>T, c.796C>A, c.803G>C, c.930G>A variants as compared with the A101 allele.
Conclusion:
Through sequencing analysis, the sample with an AwB subtype by serological testing was identified as a novel B(A) phenotype, which was unreported previously.
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