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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Pleiotropy01:33

Pleiotropy

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Expression and Function of WNT6: From Development to Disease.

Ming Wei1, Congmin Zhang2, Yujia Tian2

  • 1Department of Respiratory Medicine, The Second Hospital of Dalian Medical University, Dalian, China.

Frontiers in Cell and Developmental Biology
|January 11, 2021
PubMed
Summary

WNT family member 6 (WNT6) is crucial for development and homeostasis. Dysregulated WNT6 signaling contributes to diseases like cancer and Rett syndrome, highlighting its therapeutic potential.

Keywords:
Wnt6developmentdifferentiationdiseaseorgan formation

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • WNT family member 6 (WNT6) is a conserved protein essential for embryonic development and post-natal tissue maintenance.
  • WNT6 signaling impacts various biological processes in both mice and humans.

Purpose of the Study:

  • To review current findings on the biological functions of WNT6.
  • To elucidate WNT6's role in embryogenesis, decidualization, and organ development.
  • To explore the implications of aberrant WNT6 signaling in human diseases.

Main Methods:

  • Literature review of existing research on WNT6.
  • Analysis of WNT6's involvement in physiological processes.
  • Examination of WNT6's association with pathological conditions.

Main Results:

  • WNT6 regulates key aspects of embryogenesis, decidualization, and organ development.
  • Aberrant WNT6 signaling is linked to cancer, lung tuberculosis, and kidney fibrosis.
  • WNT6 modulation shows potential for improving Rett syndrome symptoms.

Conclusions:

  • WNT6 is a significant factor in both normal development and disease pathogenesis.
  • Understanding WNT6 mechanisms provides a basis for developing targeted therapies.
  • WNT6 presents a promising target for future research and clinical intervention.