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Critical Reviews on Pediatric Dosage Form Developments and Medical Devices

Gurkirat Kaur1, Dheeraj Nagpal1, Kalpana Nagpal1

  • 1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, U.P., India.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 11, 2021
PubMed

Insights

Pediatric drug dosing requires specialized approaches beyond adult standards. Novel formulations and medical devices like oral pens and Medibottles improve pediatric medication administration, reducing errors and toxicity.

Area of Science:

  • Pediatric Pharmacology
  • Drug Delivery Systems
  • Biopharmaceutical Sciences

Background:

  • Pediatric patients are not simply
  • miniature adults
  • due to distinct physiological differences affecting drug pharmacokinetics and pharmacodynamics.
  • Current pediatric dosing practices, often based on age, weight, or reduced adult doses, are frequently inadequate.
  • Organ development and body composition variations in children necessitate tailored pharmaceutical strategies.

Purpose of the Study:

  • To review the challenges in designing pediatric dosage forms.
  • To highlight advancements in medical devices for pediatric drug administration.
  • To emphasize the need for customized solutions to improve medication safety and efficacy in children.

Main Methods:

  • Literature review of pediatric drug formulation and delivery systems.
  • Analysis of novel medical devices designed for pediatric use.
  • Synthesis of information on challenges and innovations in pediatric pharmacotherapy.

Main Results:

  • Customized formulations like mini-tablets and oro-dispersible films address administration difficulties.
  • Innovative medical devices, including oral solid dosage pens, Nipple Shield Delivery Systems (NSDS), and Medibottles, facilitate accurate dosing.
  • These advancements offer flexibility and convenience, overcoming barriers to effective drug delivery in pediatric patients.

Conclusions:

  • Specialized dosage forms and medical devices are crucial for safe and effective pediatric drug administration.
  • Addressing unique pediatric physiological parameters is essential for optimizing therapeutic outcomes.
  • Innovations in drug delivery systems can significantly reduce medication errors, incomplete absorption, and toxicity in children.

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