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Updated: Nov 22, 2025

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Acute zonal occult outer retinopathy complex disease: Lessons learned about choroid, photoreceptors, and retinal
Francesco Pellegrini1, Daniele Cirone2, Luca De Simone3
1Department of Ophthalmology, "Ospedale Santo Spirito," AUSL Pescara, Pescara, Italy.
Purpose:
Retinal photoreceptors layer integrity is considered essential to visual function. We report a case of acute zonal occult outer retinopathy (AZOOR) complex disease (namely AIBSE: acute idiopathic blind spot enlargement) in which apparently a full anatomic regeneration is not needed for a complete functional recovery.
Methods:
Case report with multimodal imaging.
Reports:
Visual field recovery in the presence of photoreceptors layer disruption studied by means of Optical Coherence Tomography. Choroid and photoreceptors layer thickness thinned progressively during recovery.
Conclusion:
This case suggests that anatomical retinal integrity as shown by OCT does not always correspond to visual function. Our case highlights that a complete visual recovery can occur even when structural abnormalities are still observable.
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