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Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Updated: Nov 22, 2025

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Engineered protein cages for selective heparin encapsulation.

Salla Välimäki¹, Qing Liu¹, Lise Schoonen²

¹Department of Bioproducts and Biosystems, Aalto University, P.O. Box 16100, Aalto FI-00076, Espoo, Finland. mauri.kostiainen@aalto.fi.

Journal of Materials Chemistry. B

|January 11, 2021

Summary

This summary is machine-generated.

Researchers created heparin-binding protein cages using cowpea chlorotic mottle virus (CCMV) capsids. These novel assemblies show promise as safe and effective heparin antidotes due to their specific encapsulation and blood compatibility.

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Synthesis of an Intein-mediated Artificial Protein Hydrogel

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Published on: January 27, 2014

Area of Science:

Biotechnology
Materials Science
Nanotechnology

Background:

Heparin is a widely used anticoagulant, but its effects can be difficult to reverse.
Developing safe and effective heparin antidotes is crucial for clinical practice.
Current heparin reversal agents may have limitations or side effects.

Purpose of the Study:

To engineer novel protein cages for specific heparin encapsulation.
To evaluate the blood compatibility and potential antidote applications of these assemblies.
To develop a new strategy for heparin neutralization.

Main Methods:

Conjugation of a heparin-specific binding peptide to cowpea chlorotic mottle virus (CCMV) capsid protein.
Self-assembly of modified capsid proteins to encapsulate heparin.
Assessment of encapsulation specificity and hemolytic activity of the resulting assemblies.

Main Results:

Successfully formed capsid-like protein cages encapsulating heparin.
Demonstrated specific encapsulation of heparin within the protein cages.
Observed negligible hemolytic activity, indicating good blood compatibility.

Conclusions:

Engineered CCMV-based protein cages can specifically encapsulate heparin.
These heparin-encapsulating assemblies exhibit favorable blood compatibility.
The developed system shows significant potential for heparin antidote applications.