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5-Aminolevulinic acid formation from glutamate via the C5 pathway in Clostridium thermoaceticum
T Oh-hama1, N J Stolowich, A I Scott
1Department of Chemistry, Texas A&M University, College Station 77843.
FEBS Letters
|February 8, 1988
Abstract:
A cell-free extract of the anaerobic eubacterium, Clostridium thermoaceticum, catalyzes the synthesis of 5-aminolevulinic acid (ALA) from glutamate via the C5 pathway. The enzyme reaction resembles that of higher plants and algae in cofactor requirements and sensitivity to ribonuclease. From the phylogenetic distribution it is proposed that the C5 pathway evolved earlier than the ALA synthase pathway.