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Genome-wide analysis of the synonymous codon usage pattern of Streptococcus suis
Quanming Xu1, Hong Chen2, Wen Sun2
1Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Microbial Pathogenesis
|January 11, 2021
Summary
Streptococcus suis (S. suis) evolution is shaped by natural selection, with A/T-ending codons dominating its genome. This pathogen
Area of Science:
- Microbiology
- Genomics
- Evolutionary Biology
Background:
- Streptococcus suis (S. suis) is a significant pathogen affecting both humans and animals.
- Bacterial codon usage patterns offer insights into evolutionary adaptations and environmental tolerance.
Purpose of the Study:
- To investigate the genetic features and evolutionary trajectory of S. suis through codon usage analysis.
- To compare codon usage patterns between S. suis and its susceptible hosts.
Main Methods:
- Analysis of nucleotide composition and Relative Synonymous Codon Usage (RSCU) across nine S. suis strains.
- Neutrality analysis, correspondence analysis, ENC-plot, and cluster analysis based on RSCU.
- Comparison of codon usage patterns with human (H. sapiens) and swine (S. scrofa) genomes.
Main Results:
- A/T-ending codons are prevalent in S. suis.
- Natural selection is the primary driver of codon usage in S. suis.
- S. suis exhibits distinct codon usage patterns compared to its hosts, with highly expressed genes involved in metabolism and transcriptional regulation.
Conclusions:
- Codon usage in S. suis is predominantly influenced by natural selection, reflecting adaptations to diverse environments.
- The distinct codon usage highlights evolutionary divergence between S. suis and its hosts.
- This study provides insights into the molecular evolution of S. suis and its host-pathogen relationships.
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