Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Orchiectomy in horses: closed technique and primary closure of the incision.

Journal of the American Veterinary Medical Association·2026
Same author

Nature's blueprint: Exopolysaccharides linking microbiome dynamics to advanced bone tissue engineering.

Carbohydrate polymers·2026
Same author

A Single-Antenna RFID Machine Learning Approach for Direction and Orientation Tracking in Industrial Logistics.

Sensors (Basel, Switzerland)·2026
Same author

Feasibility of a hand-held myotonometry device for measuring biomechanical muscle parameters in horses.

American journal of veterinary research·2026
Same author

Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Suprainguinal Fascia Iliaca Block as Primary Anesthesia in a Child-Pugh C Patient Undergoing Percutaneous Hip Fixation: A Case Report.

Cureus·2025
Same journal

A DLP-Printed 3D Bioceramplug Fabricated Using a Photocurable Negative Thermo-Responsive Bioceramic Slurry for Cranial Burr-Hole Repair.

ACS biomaterials science & engineering·2026
Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026
Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same journal

Biomimetic 3D-Printed Resorbable Extracellular Matrix-Guided Bone Regeneration Membrane Based on a Gelatin Methacrylate/Alginate-Hydroxyapatite Composite for Maxillofacial Surgery.

ACS biomaterials science & engineering·2026
Same journal

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.

ACS biomaterials science & engineering·2026
Same journal

Retinoic Acid-Functionalized Chitosan Polycationic Conjugates for Integrated Melanoma Therapy and Antibacterial Infection Control.

ACS biomaterials science & engineering·2026
See all related articles

Related Experiment Video

Updated: Nov 21, 2025

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.4K

Microengineered Multicomponent Hydrogel Fibers: Combining Polyelectrolyte Complexation and Microfluidics.

Raquel Costa-Almeida1,2, Luca Gasperini1,2, João Borges1,2

  • 13B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal.

ACS Biomaterials Science & Engineering
|January 12, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed novel hydrogel fibers mimicking tendon tissue using microfluidics and polyelectrolyte complexation. These biocompatible fibers support tendon cell viability and function, showing potential for tissue engineering applications.

Keywords:
chondroitin sulfatefiber-based techniqueshyaluronic acidmicrofludicspolyelectrolyte complexationtendon

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.8K
Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

8.9K

Related Experiment Videos

Last Updated: Nov 21, 2025

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.4K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.8K
Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

8.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Fiber-based techniques are crucial for creating structures that replicate fibrous tissues like tendons.
  • Microfluidics and polyelectrolyte complexation are established methods for fabricating fibrous structures.

Purpose of the Study:

  • To combine microfluidics and polyelectrolyte complexation for generating hydrogel fibers with a fibrillar-like structure.
  • To investigate the potential of these novel hydrogel fibers in supporting tendon cell behavior and function.

Main Methods:

  • Fabrication of multicomponent hydrogel fibers using methacrylated hyaluronic acid (MA-HA) or methacrylated chondroitin sulfate (MA-CS) mixed with alginate (ALG) and chitosan (CHT).
  • Utilized a microfluidic device for continuous injection into a coagulation bath followed by photo-cross-linking.
  • Encapsulated and cultured tendon cells within the fabricated hydrogel fibers for biological assessment.

Main Results:

  • Successfully generated multicomponent hydrogel fibers with aligned, smaller fibrils when chitosan was included.
  • The developed process maintained tendon cell viability over 21 days of culture.
  • Encapsulated cells retained their primary function of extracellular matrix production.

Conclusions:

  • A novel class of photo-cross-linkable, multicomponent hydrogel fibers was developed.
  • These hydrogel fibers demonstrate potential as bioactive modulators of cell behavior.
  • The technique offers a promising approach for engineering tendon-like fibrous tissues.