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Human cornea: individual responses to hypoxic environments.

W J Benjamin1, R M Hill

  • 1Ohio State University, College of Optometry, Columbus 43210-1240.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Human corneas show significant differences in oxygen demand, especially under low oxygen conditions. These variations are crucial for assessing patient safety during extended contact lens wear.

Area of Science:

  • Ophthalmology
  • Physiology
  • Biomedical Engineering

Background:

  • The cornea requires oxygen for metabolic processes.
  • Hypoxic stress can affect corneal health, particularly with contact lens wear.

Purpose of the Study:

  • To measure human corneal responses to varying oxygen levels.
  • To quantify differences in corneal oxygen demand between individuals.

Main Methods:

  • Utilized a micropolarographic system to measure corneal responses.
  • Exposed seven human corneas to oxygen atmospheres from 20.9% down to 0%.

Main Results:

  • Observed oxygen demand ratios between corneas up to 1.23:1 under normal conditions.
  • Following 0% oxygen exposure, demand ratios increased significantly, reaching a maximum of 1.93:1 (nearly 2:1).

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Conclusions:

  • Individual human corneas exhibit substantial variability in oxygen demand.
  • These differences are critical for evaluating patient suitability and safety concerning hypoxic stress, such as with extended contact lens wear.