Related Experiment Video

Updated: Nov 21, 2025

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
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Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

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Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial

Gonzalo Garcia Guerra1,2, Ari R Joffe3,4, Cathy Sheppard4

  • 1Department of Pediatrics, University of Alberta, Room 4-548 11405 87 Avenue, Edmonton, AB, T6G 1C9, Canada. gonzalo.guerra@ahs.ca.

Journal of Intensive Care
|January 12, 2021
PubMed

Insights

This pilot study shows that music medicine interventions are feasible in pediatric intensive care units. The trial provided data to plan larger studies on music

Area of Science:

  • Pediatric Intensive Care Medicine
  • Music Therapy
  • Clinical Trial Design

Background:

  • Critically ill children in intensive care often require sedation and analgesia.
  • Feasibility of non-pharmacological interventions like music therapy in this population is not well-established.

Purpose of the Study:

  • To assess the feasibility of a music medicine intervention trial in pediatric intensive care.
  • To gather data on sedation and analgesia use for future larger trials.

Main Methods:

  • Pilot randomized controlled trial (RCT) involving children aged 1 month to 16 years on mechanical ventilation.
  • Patients were randomized to receive classical music, noise cancellation, or usual care.
  • Interventions were administered for 30 minutes, three times daily.

Main Results:

  • The study enrolled 60 patients with a feasible enrollment rate and acceptable consent rate.
  • Protocol adherence exceeded 80%, and no adverse events were reported.
  • A statistically significant decrease in heart rate was observed during music intervention, with positive parental feedback on comfort and child settling.

Conclusions:

  • Music medicine interventions are feasible in pediatric intensive care settings.
  • The pilot study successfully gathered essential data for designing a larger, powered clinical trial.
Abstract

Keywords:
AnalgesiaMusicNoisePediatric intensive careSedation

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