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Spontaneously regressed granulomatosis with polyangiitis: A case report
Hiroki Ota1, Chisa Sato1, Akira Igarashi1
1Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
A rare case of granulomatosis with polyangiitis (GPA) showed spontaneous lung nodule regression. Neutrophil extracellular traps (NETs) may play a role in this natural disease remission.
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Granulomatosis with polyangiitis (GPA) is a rare autoimmune vasculitis.
- Lung involvement in GPA often presents as nodular infiltrates.
Observation:
- A 71-year-old woman with GPA presented with cough, chest, and back pain.
- Chest roentgenogram revealed multiple bilateral pulmonary nodules.
Findings:
- The patient's pulmonary nodules showed spontaneous regression over several months.
- This spontaneous remission is uncommon in GPA, with unclear underlying mechanisms.
Implications:
- Neutrophil extracellular traps (NETs) are implicated in GPA pathogenesis.
- NETs might be involved in the natural regression process of GPA, warranting further investigation.
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