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Published on: July 16, 2018
Construction and evaluation of an iron delivery system by ultra-small nanoparticles from roast sturgeon (Acipenser
Yukun Song1, Kangjing Liu1, Wentao Su1
1School of Food Science and Technology, Dalian Polytechnic University, Qinggongyuan 1, Ganjingzi District, Dalian 116034, China. 2468750030@qq.com and National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China and Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.
Abstract:
Nanoparticles were extensively applied as carriers for bioactive compound delivery to improve their bio-availability. In this study, we developed novel water-soluble and ultra-small food-borne nanoparticles (FNs) from roasting sturgeon as carriers for Fe(ii) delivery. The molecular interactions between FNs and Fe(ii) ions, and the digestion and absorption of the FN-Fe(ii) complex through the gastrointestinal system were investigated. The thermodynamic analysis revealed that the FNs spontaneously interacted with Fe(ii) having negative Gibbs free energy change. The data showed that approximately one FN can bind with four Fe(ii) (n = 4.23) through hydroxyl and amino groups. Flow cytometric analysis indicated that the FN-Fe(ii) had no effect on the cell viability at concentration <1 mg mL-1. The FN-Fe(ii) complex was stable in the digestive tract with a retention rate of 95.18% ± 3.11% after gastrointestinal digestion. Moreover, 1 μg mm-2 FN-Fe(ii) complex could cross the intestinal wall for Fe(ii) delivery. This research revealed that FNs produced from roasted sturgeon have the potential as biocompatible, efficient and stable nanocarriers for Fe(ii) nutritional delivery.
