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Related Concept Videos

Histology of the Small Intestine01:27

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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
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The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
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The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
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The stomach comprises several layers that work together to facilitate digestion and protect the organ. The outermost layer is called the serosa, which provides support and protection to the stomach. The muscularis externa layer is responsible for the mechanical breakdown of food by contracting and moving the stomach. The submucosa layer, located beneath the muscularis externa, contains connective tissue, blood vessels, nerves, and glands that secrete mucus and other substances essential for...
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Related Experiment Video

Updated: Nov 21, 2025

Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti ratti Infection
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Experimental Infection of Mice with the Parasitic Nematode Strongyloides ratti ratti Infection

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Strongyloidiasis duodenum: A histopathological study.

Rimi Pandey1, Padam Kumari Agarwal1, Prashant Katiyar1

  • 1Department of Pathology, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Indian Journal of Pathology & Microbiology
|January 12, 2021
PubMed
Summary

Strongyloides stercoralis, a parasitic worm, caused severe gastrointestinal symptoms in an immunocompromised patient. Diagnosis was confirmed via duodenal biopsy, leading to successful treatment and recovery.

Keywords:
Histomorphology of Strongyloides stercoralisimmunosuppression and strongyloidiasisscleroderma with strongyloidiasis

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Generating Transgenics and Knockouts in Strongyloides Species by Microinjection
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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Parasitology

Background:

  • Strongyloides stercoralis is a soil-transmitted helminth infecting humans through skin penetration.
  • Immunocompromised individuals, such as those on corticosteroids, are at higher risk for severe or disseminated infections.
  • Systemic sclerosis is an autoimmune disease that can affect multiple organs, including the gastrointestinal tract.

Observation:

  • A 30-year-old male with systemic sclerosis on corticosteroids presented with a month of watery diarrhea, abdominal pain, fullness, anorexia, and low-grade fever.
  • Endoscopy revealed duodenal mucosa with thickened, edematous folds, pinpoint bleeding, and multiple ulcerations.
  • Histopathological examination of duodenal biopsies confirmed the presence of Strongyloides stercoralis within the mucosal glands.

Findings:

  • The histopathology definitively identified Strongyloides stercoralis infestation in the duodenum.
  • The parasite's presence was associated with significant inflammatory changes and mucosal damage in the duodenum.
  • The patient's symptoms were directly attributed to the duodenal strongyloidiasis.

Implications:

  • This case highlights the importance of considering Strongyloides stercoralis in immunocompromised patients presenting with unexplained gastrointestinal symptoms.
  • Accurate diagnosis through duodenal biopsy and histopathology is crucial for effective treatment.
  • Prompt treatment of strongyloidiasis in immunocompromised hosts can prevent severe complications and ensure a favorable outcome.