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Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
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A minimal model for household-based testing and tracing in epidemics.

Greg Huber1, Mason Kamb1, Kyle Kawagoe2

  • 1Chan Zuckerberg Biohub, San Francisco, CA 94158, United States of America.

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Summary

This study proposes a minimal virus testing and tracing strategy for stratified populations. It involves random population testing and full household testing of positive cases to estimate required testing frequency.

Keywords:
COVID-19SARS-CoV-2confinement strategiesepidemiologypandemicstesting and tracing

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Area of Science:

  • Epidemiology
  • Infectious disease modeling
  • Public health strategies

Background:

  • Previous work modeled virus transmission dynamics with clustered contacts (household vs. inter-household).
  • Understanding effective testing and tracing is crucial for controlling infectious disease outbreaks in stratified populations.

Purpose of the Study:

  • To propose and evaluate a minimal testing and tracing strategy for populations with clustered contact structures.
  • To determine the necessary testing frequency for the proposed strategy's efficacy.

Main Methods:

  • The study proposes a minimal tracing strategy combining random population-wide testing with comprehensive testing of contacts within households of identified positive individuals.
  • Mathematical modeling and simulation approaches are implied for estimating testing frequency.

Main Results:

  • The proposed strategy aims to balance resource allocation with effective disease surveillance.
  • Estimates for the required testing frequency to ensure the strategy's success are provided.

Conclusions:

  • A combined random and targeted household testing approach offers a potentially efficient method for virus surveillance in stratified populations.
  • The findings provide practical insights into optimizing public health interventions for infectious disease control.