Does Abelmoschus esculentus act as antidiabetic? A systematic review with updated evidence

Area of Science:

• Integrative and Complementary Medicine
• Nutritional Science
• Pharmacognosy

Background:

• Diabetes mellitus is a leading cause of mortality and morbidity worldwide.
• Current treatments for diabetes mellitus have limitations and potential toxic side effects.
• Natural remedies, particularly plant-based options, are being explored as alternative therapeutic approaches.

Purpose of the Study:

• To conduct a comprehensive evidence-based rapid review on the effects of Abelmoschus esculentus on diabetes mellitus.
• To summarize the molecular evidence, nutritional and phytochemical components, and clinical/pre-clinical data related to Abelmoschus esculentus and diabetes.
• To provide an overview of the current evidence for potential use in diabetes management.

Main Methods:

• A systematic search of major scientific databases (PubMed, Medline, Embase, CINAHL, Scopus) was performed up to July 30, 2020.
• Keywords used included "Abelmoschus esculentus," "lady's finger," and "diabetes mellitus."
• A narrative summary approach was employed for data synthesis due to heterogeneity in the included studies; meta-analysis was not performed.

Main Results:

• Twenty-one studies were identified and included in this evidence-based review.
• The review synthesizes information on the nutritional profile, phytochemical constituents, and observed effects of Abelmoschus esculentus in both human and animal models of diabetes.
• Evidence suggests potential benefits, but further investigation is warranted.

Conclusions:

• Abelmoschus esculentus presents a promising natural alternative for managing diabetes mellitus.
• The findings highlight the need for more in-depth human studies to validate its efficacy and safety.
• This review serves as a knowledge base for clinicians and researchers interested in plant-based diabetes interventions.