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Updated: Nov 21, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
Investigating the association between chronological age and thyroid cartilage ossification using CT imaging
Seyed Morteza Tabatabaee1, Maryam Vasheghani Farahani2, Alimohammad Alimohammadi3
1AJA University of medical sciences, Tehran, Iran.
Thyroid cartilage ossification, including its volume and Hounsfield score, can help estimate age and determine sex. These CT scan-based measures, combined with anthropometric data, offer insights into forensic age estimation.
Area of Science:
- Forensic Anthropology
- Radiology
- Anatomical Pathology
Background:
- Thyroid cartilage ossification progresses with age, offering potential for age estimation.
- Existing age estimation methods can be supplemented by assessing ossified volume.
- This study investigates anthropometric and ossified volume correlations with age using CT imaging.
Purpose of the Study:
- To evaluate the correlation between anthropometric characteristics and ossified volume of the thyroid cartilage with chronological age.
- To assess the utility of CT scan-derived measures for age estimation.
- To explore the potential of thyroid cartilage morphology for sex determination.
Main Methods:
- 100 thyroid cartilages from Iranian corpses (60 male, 40 female) were analyzed.
- CT scans were used to measure ossified volume and Hounsfield score via 3D reconstruction.
- Pearson's correlation and ANOVA tests were employed for statistical analysis.
Main Results:
- Thyroid cartilage measures were generally larger in males than females.
- Height of laminae and depth of thyroid notch showed significant correlations with age.
- Ossified volume and Hounsfield score correlated with chronological age but not specific age groups.
Conclusions:
- Combined anthropometric and CT scan measures (ossified volume, Hounsfield score) provide low-precision age estimation.
- Thyroid cartilage measurements are valuable for sex determination.
- Further research may refine the use of these parameters in forensic contexts.
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