Related Experiment Video
Updated: Nov 21, 2025

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
Published on: April 26, 2024
Acute lymphoid leukemia etiopathogenesis
Thiago Cezar Fujita1, Nathália Sousa-Pereira1, Marla Karine Amarante2
1Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR, Brazil.
This review examines environmental factors contributing to acute lymphoid leukemia (ALL), a childhood cancer affecting blood precursor cells. Understanding these exogenous influences is crucial for leukemia research and prevention strategies.
Area of Science:
- Hematology
- Oncology
- Environmental Health
Background:
- Acute lymphoid leukemia (ALL) is a hematological neoplasm impacting B, T, and NK precursor cells, predominantly in children.
- Leukemogenesis in ALL involves complex interactions between genetic and environmental factors, leading to lymphoid precursor cell abnormalities.
- Existing literature presents conflicting results regarding the role of environmental factors in ALL development.
Purpose of the Study:
- To review and discuss the major exogenous (environmental) factors implicated in the development of acute lymphoid leukemia (ALL).
Main Methods:
- Literature review focusing on studies investigating environmental exposures and their association with ALL.
- Synthesis of current evidence on exogenous factors influencing leukemogenesis.
Main Results:
- Environmental factors are evaluated as potential predisposing elements in ALL.
- Conflicting results persist in the global literature regarding the specific impact of various environmental factors.
Conclusions:
- Further research is needed to clarify the role of environmental factors in ALL etiology.
- Identifying key environmental triggers could inform targeted prevention and intervention strategies for childhood leukemia.
More Related Videos
Related Concept Videos
Cells of the Adaptive Immune Response
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Immunodeficiency Diseases
There are three main causes of immunodeficiency...

