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MRI-guided radiation therapy (MRgRT) systems showed variations in their imaging center (isocenter) at different gantry positions. The MR-LINAC system exhibited greater isocenter variation than the MR-Cobalt-60 system, warranting further investigation.

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Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Diagnostic Imaging

Background:

  • Magnetic Resonance image-guided radiation therapy (MRgRT) integrates MRI for real-time treatment visualization.
  • Accurate localization of the imaging isocenter is critical for precise radiation delivery in MRgRT.
  • Variations in the MRI isocenter can compromise treatment accuracy.

Purpose of the Study:

  • To characterize and quantify MRI isocenter variations at various gantry positions in two 0.35 T MRgRT systems.
  • To evaluate the performance of two independent methods for measuring MRI isocenter variation.
  • To compare the isocenter stability between an MR-LINAC and an MR-Cobalt-60 system.

Main Methods:

  • Image center-based quantification using 3D volumetric and 2D cine phantom images at different gantry angles in MRI QA mode.
  • Image registration-based quantification using 3D MRIs and CT planning data in radiotherapy mode, analyzing couch shifts.
  • Star-shot pattern measurements on radio-chromic film for verification of isocenter variations.

Main Results:

  • Both MRgRT systems demonstrated field inhomogeneities <5 ppm over a 24 cm DSV and spatial integrity distortion <2 mm within 175 mm radius.
  • The MR-LINAC system showed a noticeable 3D MRI isocenter variation (max 1.8 mm) compared to the MR-Cobalt-60 system (max 0.9 mm).
  • 2D sagittal cine images revealed maximum MRI isocenter variations of 0.9 mm for MR-LINAC and 0.5 mm for MR-Cobalt-60.

Conclusions:

  • Two independent methods effectively quantified MRI isocenter variation across different gantry positions in 0.35 T MRgRT systems.
  • The MR-LINAC system exhibited significantly greater MRI isocenter variation than the MR-Cobalt-60 system.
  • The observed isocenter variation in the MR-LINAC system necessitates further investigation to identify the underlying causes.