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Bioresponsive microlasers with tunable lasing wavelength.

Zhiyi Yuan1, Xiaotian Tan, Xuerui Gong

  • 1School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. yucchen@ntu.edu.sg.

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Summary

Bioresponsive microlasers leverage interfacial energy transfer for sensitive molecular detection. These novel whispering-gallery-mode microdroplet cavities enable tunable lasing wavelengths, advancing bio-photonic device development.

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Area of Science:

  • Biophotonics
  • Materials Science
  • Molecular Biology

Background:

  • Lasing particles amplify light-matter interactions at the biointerface.
  • Implementing micro- and nanolasers in biological systems is advancing imaging and monitoring.
  • Developing surface-functionalized lasing particles with high Q-factor and low mode-volume remains a challenge.

Purpose of the Study:

  • To introduce a novel concept of bioresponsive microlasers.
  • To exploit interfacial energy transfer in whispering-gallery-mode (WGM) microdroplet cavities for tunable lasing.
  • To demonstrate molecular binding-induced spectral changes for biodetection.

Main Methods:

  • Utilized whispering-gallery-mode (WGM) microdroplet cavities.
  • Exploited interfacial energy transfer for gain spectrum manipulation.
  • Demonstrated protein-based and enzymatic-based molecular interactions.
  • Employed different donor/acceptor pairs to tune lasing wavelengths.

Main Results:

  • Achieved bioresponsive microlasers based on interfacial energy transfer.
  • Demonstrated tunable lasing wavelengths by controlling molecular binding concentrations.
  • Successfully implemented protein-based and enzymatic-based detection.
  • Showcased tunable lasing over a broad spectral range using selected donor/acceptor pairs.

Conclusions:

  • This study presents a novel approach for developing functional microlasers.
  • The developed bioresponsive microlasers offer new avenues for sensitive biodetection.
  • Insights into molecular modulation of laser light at the biointerface are provided.
  • This work lays the foundation for smart bio-photonic devices at the molecular level.