Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pedigree Analysis01:35

Pedigree Analysis

87.7K
Overview
87.7K
Sex-linked Disorders01:43

Sex-linked Disorders

105.8K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
105.8K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.1K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.9K
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.2K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.2K
Genetic Lingo01:11

Genetic Lingo

111.4K
Overview
111.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tolerability of clobazam as add-on therapy in patients aged 50 years and older with drug-resistant epilepsy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2023
Same author

Neuropsychiatric Manifestations of Autoimmune Encephalitis in a Tertiary Hospital: A Case Series and Current Perspectives.

The Journal of clinical psychiatry·2022
Same author

Infectious Causes of Stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2022
Same author

Clinical features with anti fibroblast growth factor receptor 3 (FGFR3) antibody-related polyneuropathy: a retrospective study.

BMC neurology·2021
Same author

Cerebral Venous Thrombosis: A Comprehensive Review.

European neurology·2020
Same author

Primary Central Nervous System Lymphoma Presenting as Parkinsonism with Atypical MRI Findings and Elevated 14-3-3 Protein.

Journal of neurosciences in rural practice·2020
Same journal

Primary Sjogren syndrome with suspected central nervous system inflammatory involvement.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Efficacy of repetitive transcranial magnetic stimulation for post-stroke spasticity: a meta-analysis of randomized controlled trials.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Diverging trends in motor neuron disease burden in China: an ageing-driven increase despite declining age-standardised rates - a GBD 2021 analysis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Efficacy and safety of extended-interval dosing of natalizumab in multiple sclerosis: a systematic review and meta-analysis with subgroup evaluation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Ultrashort echo time magnetic resonance angiography for embolized intracranial aneurysm with coil protrusion into the small parent vessel in the posterior circulation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Mixing apples and antibodies: when the Cochrane average obscures the evidence in Alzheimer's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
See all related articles

Related Experiment Video

Updated: Nov 21, 2025

Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia
07:32

Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia

Published on: February 9, 2020

8.1K

Hereditary spastic paraplegia.

Sireesha Murala1, Elanagan Nagarajan2, Pradeep C Bollu3

  • 1Department of Neurology, University of Missouri, Columbia, MO, USA. siri.murala@gmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|January 13, 2021
PubMed
Summary
This summary is machine-generated.

Hereditary spastic paraplegias (HSPs) are neurodegenerative disorders affecting corticospinal tracts, causing lower limb spasticity. This review covers HSP classification, pathology, and diagnosis for better understanding of these rare conditions.

Keywords:
Autosomal dominant HSPAutosomal recessive HSPDifferential diagnosisHereditary spastic paraplegiaTreatmentX-linked

More Related Videos

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.6K
Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

21.0K

Related Experiment Videos

Last Updated: Nov 21, 2025

Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia
07:32

Analyzing Mitochondrial Transport and Morphology in Human Induced Pluripotent Stem Cell-Derived Neurons in Hereditary Spastic Paraplegia

Published on: February 9, 2020

8.1K
Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.6K
Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury
10:49

Intraspinal Cell Transplantation for Targeting Cervical Ventral Horn in Amyotrophic Lateral Sclerosis and Traumatic Spinal Cord Injury

Published on: September 18, 2011

21.0K

Area of Science:

  • Neurology
  • Neuroscience
  • Genetics

Background:

  • Hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative disorders.
  • They are characterized by progressive spasticity and weakness in the lower extremities due to corticospinal tract involvement.
  • The prevalence is approximately 1.8 per 100,000 individuals.

Purpose of the Study:

  • To provide a comprehensive overview of Hereditary Spastic Paraplegias (HSPs).
  • To detail the classification systems for HSPs based on inheritance, clinical presentation, and molecular mechanisms.
  • To discuss the neuropathological hallmarks and differential diagnosis of HSPs.

Main Methods:

  • This review synthesizes existing literature on Hereditary Spastic Paraplegias.
  • It focuses on classification, neuropathology, and diagnostic approaches.
  • Information is compiled from various sources to provide a holistic view.

Main Results:

  • HSPs are classified by inheritance patterns (autosomal dominant, autosomal recessive) and clinical/molecular features.
  • The primary neuropathological finding is axonal degeneration of the lateral corticospinal tracts.
  • Differential diagnosis requires careful consideration of clinical and genetic factors.

Conclusions:

  • Accurate classification and understanding of neuropathology are crucial for diagnosing and managing HSPs.
  • Further research into molecular mechanisms can improve therapeutic strategies.
  • Comprehensive diagnostic approaches are essential for differentiating HSPs from other neurological conditions.