Related Experiment Video
Updated: Nov 21, 2025
08:22
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
Published on: June 20, 2025
277
Microbiome and ischemic stroke: A systematic review
Yee Teng Lee1, Nor Ismaliza Mohd Ismail1, Loo Keat Wei1
1Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.
Plos One
|January 13, 2021
Summary
This systematic review explores the link between the human microbiome and ischemic stroke. Findings suggest aging and inflammation influence microbial composition, impacting stroke risk and outcomes.
Area of Science:
- Neurology
- Microbiology
- Immunology
Background:
- Ischemic stroke is a leading cause of death globally.
- The connection between the human microbiome and ischemic stroke was previously unclear.
Purpose of the Study:
- To systematically review the existing literature on the relationship between the human microbiome and ischemic stroke.
Main Methods:
- A systematic review of articles was conducted.
- Data was extracted from eligible studies published up to October 22, 2020.
Main Results:
- Eighteen studies were included, indicating aging, inflammation, and microbial composition influence ischemic stroke.
- Microbiota-derived short-chain fatty acids and trimethylamine N-oxide play key roles.
- Phyla Firmicutes and Bacteroidetes impact post-stroke outcomes.
Conclusions:
- This is the first systematic review on the microbiome-ischemic stroke relationship.
- Aging and inflammation drive microbial changes that increase ischemic stroke susceptibility.
Related Concept Videos
01:17Ischemic Heart Disease: Overview
2.3K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.3K
01:29Microorganisms in Medicine and Therapeutics
673
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
673