Enhanced Oral Bioavailability of Resveratrol by Using Neutralized Eudragit E Solid Dispersion Prepared via Spray...

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Trans-resveratrol exhibits poor aqueous solubility, limiting its therapeutic and nutraceutical applications.
• Amorphous solid dispersions are a strategy to improve the bioavailability of poorly soluble compounds.

Purpose of the Study:

• To design and characterize amorphous solid dispersions of trans-resveratrol using Eudragit E/HCl.
• To evaluate the dissolution enhancement and in vivo pharmacokinetic profile of trans-resveratrol from these solid dispersions.

Main Methods:

• Amorphous solid dispersions were prepared using spray drying.
• Solid-state characterization included powder X-ray diffraction and scanning electron microscopy.
• In vitro dissolution and in vivo pharmacokinetic studies in rats were conducted.

Main Results:

• Eudragit E/HCl demonstrated superior solubilization of trans-resveratrol compared to other polymers.
• The optimal 10/90 trans-resveratrol/Eudragit E/HCl dispersion maintained supersaturation for 48 hours.
• Absolute oral bioavailability of trans-resveratrol reached 40% in rats.

Conclusions:

• Trans-resveratrol-loaded Eudragit E/HCl solid dispersions are a promising formulation for enhancing oral bioavailability.
• This approach supports the development of effective health supplements, nutraceuticals, and pharmaceuticals.
• Spray-dried Eudragit E/HCl solid dispersions offer a viable strategy for improving trans-resveratrol delivery.