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Updated: Nov 21, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Impact of occupational lead exposure on nerve conduction study data
Tülin Aktürk1, Gülay Çeliker2, Hikmet Saçmacı1
1Department of Neurology, Yozgat Bozok University School of Medicine, Yozgat, Turkey.
Introduction:
To investigate nerve conduction data of lead exposed workers.
Methods:
A total of 287 subjects, consisting of 197 lead exposed workers and 90 healthy controls were included. Nerve conduction study of motor (median, ulnar, peroneal and tibial) and sensory (median, ulnar and sural) nerves were performed. The data were analyzed as two and three groups.
Results:
The median blood lead level was 40.90 µg/dl. Median sensory, ulnar motor, and ulnar sensory conduction velocity were lower; distal latency of median motor, median sensory and sural sensory were longer than the controls (p < 0.05). There was no difference between the groups in terms of amplitudes.
Discussion:
This study was indicated the neurotoxic effect of lead exposure may occur in the peripheral nerves, while the mean blood lead level is 40 µg/dl.

