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Related Concept Videos

Complement System01:27

Complement System

6.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Pneumonia II: Pathophysiology01:29

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The pathophysiology of pneumonia involves the following steps:
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Pneumonia III: Complications and Assessment01:30

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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COPD: Pathogenesis and Clinical Features01:20

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Antimicrobial Proteins01:23

Antimicrobial Proteins

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Related Experiment Video

Updated: Nov 21, 2025

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.9K

Multi-organ complement deposition in COVID-19 patients.

Paolo Macor, Paolo Durigutto, Alessandro Mangogna

    Medrxiv : the Preprint Server for Health Sciences
    |January 14, 2021
    PubMed
    Summary

    Complement activation was found in the lungs, kidneys, and liver of COVID-19 patients. This tissue-level complement deposition, via classical and alternative pathways, highlights the multi-organ impact of SARS-CoV-2 infection.

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    Related Experiment Videos

    Last Updated: Nov 21, 2025

    Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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    Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

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    Depletion of Specific Cell Populations by Complement Depletion
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    Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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    Area of Science:

    • Immunology
    • Pathology
    • Virology

    Background:

    • Circulating complement activation products are elevated in COVID-19.
    • Limited data exists on complement's role at the tissue level in COVID-19.
    • Mechanisms of local complement activation in COVID-19 remain unclear.

    Conclusions:

    • Classical and alternative complement pathway activation occurs in multiple organs during severe COVID-19.
    • Complement deposition in tissues supports the multi-organ nature of COVID-19 pathology.
    • Findings provide insights into the local inflammatory processes driven by complement in COVID-19.