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Association Between GlycA and Cognitive Function: Cross-Sectional Results From the ELSA-Brasil Study
Viviane Calice-Silva1,2, Claudia K Suemoto2,3, Andre R Brunoni2,4
1Pro-rim Foundation, Joinville.
Alzheimer Disease and Associated Disorders
|January 14, 2021
Summary
Higher levels of GlycA, a marker of inflammation, are linked to poorer cognitive function, including language and executive skills. This suggests GlycA may serve as a biomarker for cognitive impairment.
Area of Science:
- Neuroscience
- Biomarkers
- Inflammation Research
Background:
- Systemic inflammation is linked to cognitive decline.
- GlycA (N-acetyl-β-D-glucosamine) is an emerging marker for inflammation.
- Limited research exists on the association between GlycA and cognitive performance.
Purpose of the Study:
- To investigate the relationship between GlycA levels and cognitive performance.
- To evaluate GlycA as a potential biomarker for cognitive impairment.
- To analyze data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
Main Methods:
- Cross-sectional study design.
- Inclusion of 4327 participants from the ELSA-Brasil cohort.
- Cognitive function assessed using word list, trail-making, and verbal fluency tests.
- Linear regression models used to analyze GlycA association with cognition, adjusting for confounders and C-reactive protein.
Main Results:
- Higher GlycA levels were significantly associated with lower global cognitive performance.
- This association remained significant after adjusting for confounders and C-reactive protein.
- Elevated GlycA levels correlated with reduced performance in language and executive function domains.
Conclusions:
- GlycA is associated with worse cognitive performance in a large Brazilian adult sample.
- GlycA may represent a valuable biomarker for identifying cognitive impairment, independent of C-reactive protein.
- Further research is warranted to explore the clinical utility of GlycA in cognitive health.
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