Combined Chemo-photothermal Antitumor Therapy Using Molybdenum Disulfide Modified with Hyperbranched Polyglycidyl

Area of Science:

• Biomaterials Science
• Nanotechnology
• Cancer Therapy

Background:

• Molybdenum disulfide (MoS₂) shows promise in cancer therapy as a photothermal agent and drug carrier.
• Poor aqueous dispersibility and stability of MoS₂ hinder its clinical application.
• Linear polymers improve MoS₂ properties but may have limitations in circulation.

Purpose of the Study:

• To develop a stable, hyperbranched polyglycidyl (HPG)-modified MoS₂ (MoS₂-HPG) for enhanced cancer treatment.
• To evaluate MoS₂-HPG as a drug delivery system for doxorubicin hydrochloride (DOX).
• To investigate the efficacy of combined chemo-photothermal therapy using MoS₂-HPG-DOX.

Main Methods:

• Synthesis of MoS₂-HPG via surface adsorption of HPG onto MoS₂.
• Characterization of physicochemical, photothermal, and biocompatibility properties of MoS₂-HPG.
• In vitro evaluation of combined chemo-photothermal therapy efficacy using MoS₂-HPG-DOX.

Main Results:

• MoS₂-HPG exhibited excellent dispersion and stability in aqueous solutions.
• High photothermal conversion efficiency and good in vitro biocompatibility were observed for MoS₂-HPG.
• MoS₂-HPG-DOX demonstrated superior anticancer effects compared to individual therapies.

Conclusions:

• MoS₂-HPG offers improved properties for cancer therapy applications.
• Combined chemo-photothermal therapy using MoS₂-HPG-DOX is a potent strategy against cancer.
• MoS₂-HPG holds potential as a therapeutic formulation for clinical cancer treatment.