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Smart and Biostable Polyurethanes for Long-Term Implants.

Seungil Kim1, Song Liu1,2,3

  • 1Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

ACS Biomaterials Science & Engineering
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

This review covers stimuli-responsive and biostable polyurethanes (PUs) for long-term medical implants. Smart PUs show promise for artificial blood vessels and intervertebral discs, enhancing biocompatibility.

Keywords:
biostable polyurethanelong-term implantspolyurethane biomaterialssmart polyurethane

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Polyurethanes (PUs) are versatile polymers with significant biomedical potential.
  • Stimuli-responsive and biostable PUs are emerging as advanced biomaterials.
  • Long-term implantable devices require materials with high biostability and tailored responses.

Purpose of the Study:

  • To review recent advancements in stimuli-responsive and biostable polyurethanes (PUs).
  • To discuss the biomedical applications of smart PUs, focusing on long-term implants.
  • To explore the future outlook for smart biostable PU biomaterials.

Main Methods:

  • Literature review of recent publications and inventions.
  • Analysis of research on stimuli-responsive and biostable PU properties.
  • Discussion of specific applications like artificial blood vessels, intervertebral discs (IVDs), and intravaginal rings (IVRs).

Main Results:

  • Smart PUs are being developed to improve bioactivity, biocompatibility, and reduce adverse effects.
  • Biostability is crucial for long-term implantable PU biomaterials, distinguishing them from biodegradable materials for regenerative medicine.
  • Recent research highlights progress in stimuli-responsive and biostable PU development.

Conclusions:

  • Stimuli-responsive and biostable PUs offer significant potential for advanced long-term implantable biomedical devices.
  • Continued research into smart PUs is expected to enhance their performance and expand their clinical applications.
  • The focus on biostability is key for the success of PUs in demanding long-term implant scenarios.