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Cardiovascular Aging and Longevity: JACC State-of-the-Art Review
Panagiota Pietri1, Christodoulos Stefanadis1
1Athens Medical School, University of Athens, Athens, Greece; Research Institute for Longevity and Aging-related diseases, Athens, Greece.
Insights
Cardiovascular aging and longevity are linked by shared mechanisms. Understanding these links can inform interventions to promote heart health and extend lifespan.
Area of Science:
- Cardiovascular Science
- Gerontology
- Genetics
Background:
- Cardiovascular aging and longevity share common pathophysiological pathways.
- Factors promoting atherosclerotic cardiovascular disease are often implicated in aging, and vice versa.
- Cardiometabolic disorders like hyperglycemia, insulin resistance, dyslipidemia, and hypertension are linked to aging mechanisms.
Purpose of the Study:
- To describe the pathophysiological links between cardiovascular aging and longevity.
- To translate aging and longevity mechanisms into clinical data.
- To identify genetic, dietary, and environmental factors in long-living populations.
Main Methods:
- Review of existing literature on aging, longevity, and cardiovascular disease.
- Analysis of genetic, molecular, and biochemical pathways.
- Correlation of aging mechanisms with clinical data from long-living individuals.
Main Results:
- Shared mechanisms identified between cardiovascular aging and longevity.
- Genetic modulators of longevity significantly impact cardiovascular aging.
- Commonalities in aging and cardiometabolic disorders highlighted.
Conclusions:
- Knowledge of aging pathways can guide interventions to delay cardiovascular aging.
- Interventions targeting aging mechanisms may promote longevity.
- Genetic, dietary, and environmental factors are crucial in long-living populations.
Abstract:
Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.
