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Breast-implant-associated anaplastic large-cell lymphoma.

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Breast-implant-associated anaplastic large-cell lymphoma.

S Ozalla Samaniego1, G Meijide Santos2, M Soto Dopazo3

  • 1Unidad de Mama, Servicio de Radiodiagnóstico, Hospital Universitario de Cabueñes, Gijón, España.

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Summary

Breast-implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare cancer linked to textured breast implants. Early diagnosis via fluid analysis and implant removal offers a good prognosis for patients with BIA-ALCL.

Keywords:
AnaplasticAnaplásicoBreast implantsCélula grandeImplantes mamariosLarge cellLinfomaLymphomaSeroma

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Area of Science:

  • Oncology
  • Pathology
  • Medical Devices

Background:

  • Breast-implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma.
  • It is exclusively associated with textured breast implants, typically presenting years after implantation.
  • Common presentations include peri-implant effusion or a palpable mass.

Purpose of the Study:

  • To present a case of BIA-ALCL with both effusion and a nodule.
  • To highlight diagnostic and management strategies for BIA-ALCL.
  • To emphasize the importance of multidisciplinary care and regulatory notification.

Main Methods:

  • Diagnosis of BIA-ALCL confirmed by cytological and histological analysis.
  • Ultrasound-guided fine-needle aspiration for effusion.
  • Core-needle biopsy for suspected masses.
  • Surgical removal of implants and capsulectomy.

Main Results:

  • The case presented with peri-implant effusion and an incipient nodule in a patient with textured implants.
  • Immunophenotyping showed CD30 expression and ALK negativity.
  • Treatment involved implant removal and bilateral capsulectomy.

Conclusions:

  • BIA-ALCL requires a multidisciplinary approach involving oncologists, surgeons, and pathologists.
  • Prompt diagnosis and treatment, including implant removal, are crucial.
  • Notification to regulatory agencies like the Spanish Agency of Medicines and Medical Devices (AEMPS) is essential for disease surveillance.