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Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review
Vandan D Upadhyaya1, Steven Douedi1, Brandon Garcia2
1Department of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA.
Abstract:
Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.
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