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Updated: Nov 21, 2025

Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats
Published on: January 31, 2019
Beat-to-beat blood pressure measurement using a cuffless device does not accurately reflect invasive blood pressure
Mohammed A Moharram1, Luke C Wilson1, Michael Ja Williams1
1Department of Medicine - HeartOtago, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Insights
A new cuffless blood pressure (BP) monitor showed significant bias compared to invasive and cuff-based BP measurements. This beat-to-beat (BtB) device is not suitable for clinical or research use.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Medical Device Technology
Background:
- Continuous, cuffless blood pressure (BP) monitoring offers a potential alternative to invasive and intermittent cuff-based methods.
- Investigating the accuracy of cuffless beat-to-beat (BtB) BP devices is crucial for clinical adoption.
- Current limitations necessitate validation against established BP measurement techniques.
Purpose of the Study:
- To evaluate the accuracy of a specific cuffless BtB BP device (SOMNOtouch NIBP).
- To compare BtB BP measurements against both invasive BP (iBP) and brachial cuff BP (cBP).
- To determine the suitability of the BtB device for clinical and research applications.
Main Methods:
- A cohort of patients undergoing coronary angiography (CA) and/or percutaneous coronary intervention (PCI) was recruited.
- The BtB device was calibrated to an initial cBP reading.
- Simultaneous BP measurements were taken using the BtB device, iBP, and cBP at two distinct time points.
Main Results:
- The study was prematurely terminated due to significant measurement bias.
- Analysis of 14 participants revealed that BtB BP readings were consistently higher than iBP.
- A substantial bias was observed between BtB BP and iBP (SBP: 34.3 mmHg, DBP: 23.6 mmHg), and a similar bias existed between BtB BP and cBP.
Conclusions:
- Significant discrepancies exist between the tested BtB BP device and both invasive and cuff-based BP measurements in patients undergoing CA/PCI.
- The non-invasive BtB BP monitoring device demonstrated unsuitability for clinical or research use.
- Further development and validation are required for cuffless BP monitoring technologies.
Background:
The availability of an accurate continuous cuffless blood pressure (BP) monitor would provide an alternative to both invasive continuous BP and 24-h intermittent cuff-based BP monitors. We investigated the accuracy of a cuffless beat to beat (BtB) device compared to both invasive BP (iBP) and brachial cuff BP (cBP) measurements.
Methods:
Patients undergoing clinically indicated coronary angiography (CA) and/or percutaneous coronary intervention (PCI) were recruited. After calibration to an initial cBP reading, BP was measured simultaneously using a BtB device (SOMNOtouch NIBP), brachial artery iBP, and cBP at two time points.
Results:
The study was terminated early due to a significant bias. Recordings from 14 participants (11 males, mean age 68.4 years) were analysed. Readings from BtB BP were higher than iBP. The bias between BtB BP and iBP was 34.3 mmHg (95%CI: 27.0, 41.5) and 23.6 mmHg (95%CI: 16.8, 30.4) for SBP and DBP respectively. A similar bias was seen between BtB BP and cBP, but cBP and iBP were largely in agreement.
Conclusions:
In patients undergoing CA/PCI, significant differences were detected between BtB BP and both invasively measured and cuff BP. The non-invasive BtB BP measurement device tested is not suitable for clinical or research use.
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