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Updated: Nov 21, 2025

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Circulating tumor cell profiling for precision oncology.

Mahmoud Labib1, Shana O Kelley1,2,3,4

  • 1Department of Pharmaceutical Sciences, University of Toronto, Canada.

Molecular Oncology
|January 15, 2021
PubMed
Summary
This summary is machine-generated.

Circulating tumor cells (CTCs) analysis reveals links between their molecular profiles and treatment response in precision oncology. Overcoming current limitations requires advanced analytics for broader clinical implementation.

Keywords:
CTC enrichmentdrug selectionmicrofluidicsmolecular profilingprecision oncologytumor resistance

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Circulating tumor cells (CTCs) are valuable biomarkers in precision oncology.
  • Advances in profiling enable correlation of CTC molecular profiles with therapeutic outcomes.
  • Tumor resistance mechanisms are increasingly linked to CTC properties.

Purpose of the Study:

  • To review mechanisms of tumor resistance and their association with CTCs.
  • To summarize CTC isolation and analysis technologies.
  • To discuss clinical studies on CTCs as predictors of therapy response.

Main Methods:

  • Review of existing literature on CTCs, tumor resistance, and precision oncology.
  • Summary of technologies for CTC isolation and molecular profiling (genomic and proteomic).
  • Analysis of clinical studies investigating CTCs for treatment response prediction.

Main Results:

  • Established association between CTC molecular profiles and tumor response to therapy.
  • Identified key technologies for CTC analysis.
  • Highlighted clinical evidence linking CTCs to treatment responsiveness.
  • Outlined current limitations hindering clinical adoption of CTC analysis.

Conclusions:

  • CTCs offer significant potential for guiding precision oncology treatments.
  • Further development is needed to overcome limitations in CTC implementation.
  • Multiparametric approaches and advanced data analytics are crucial for future clinical utility.