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Frequency-dependent Selection01:21

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DILS: Demographic inferences with linked selection by using ABC.

Christelle Fraïsse1,2, Iva Popovic3, Clément Mazoyer2

  • 1Institute of Science and Technology Austria, Klosterneuœburg, Austria.

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|January 15, 2021
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Summary
This summary is machine-generated.

We developed DILS, a statistical platform for demographic inference from population genomic data. It identifies demographic models, genomic heterogeneity, and gene flow barriers, aiding speciation genomics research.

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Area of Science:

  • Population genomics
  • Evolutionary biology
  • Bioinformatics

Background:

  • Understanding population dynamics and genetic divergence is crucial for speciation research.
  • Linked selection can obscure demographic signals in genomic data.
  • Existing tools may not fully integrate demographic modeling with the detection of selection-linked genomic heterogeneity.

Purpose of the Study:

  • To introduce DILS, a novel statistical analysis platform for demographic inference using population genomic data.
  • To enable the identification of demographic models, genomic heterogeneity due to linked selection, and barriers to gene flow.
  • To facilitate collaborative speciation genomics research through a user-friendly web interface.

Main Methods:

  • Approximate Bayesian Computation (ABC) framework for statistical inference.
  • Hierarchical analysis of single- or two-population multilocus sequence data.
  • Simulation-based performance evaluation and application to empirical Mytilus mussel data.

Main Results:

  • DILS successfully identifies demographic models, including gene flow and population size changes.
  • The platform detects genomic heterogeneity in effective size (Ne) and migration rate (Nm), indicative of linked selection.
  • DILS pinpoints genomic regions associated with barriers to gene flow, validated through simulations and empirical data.

Conclusions:

  • DILS provides a robust framework for demographic inference and detecting linked selection in population genomic data.
  • The platform aids in understanding the genomic basis of speciation by identifying gene flow barriers.
  • DILS is a valuable tool for collaborative research in evolutionary and speciation genomics.