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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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COVID-19 and acute kidney injury

Lale A Ertuğlu1, Asiye Kanbay2, Barış Afşar3

  • 1Department of Internal Medicine, Koc University School of Medicine, Istanbul, Turkey.

Tuberkuloz Ve Toraks
|January 15, 2021
PubMed

Insights

COVID-19 significantly impacts kidneys, causing acute kidney injury (AKI) in severe cases. Understanding AKI mechanisms and implementing protective measures is crucial for patient outcomes.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Virology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has led to widespread health issues globally.
  • Kidney damage, including proteinuria, hematuria, and AKI, is frequently observed in hospitalized COVID-19 patients.
  • Acute kidney injury (AKI) is particularly common in severe and critical COVID-19 cases and is linked to increased mortality.

Purpose of the Study:

  • To review the prevalence and outcomes of AKI in COVID-19 patients.
  • To explore the potential mechanisms underlying COVID-19-associated kidney damage.
  • To suggest strategies for preventing kidney injury in COVID-19.

Main Methods:

  • Review of current literature on COVID-19 and kidney injury.
  • Analysis of histopathological findings in kidney tissues from COVID-19 patients.
  • Discussion of potential therapeutic targets and organ-protective measures.

Main Results:

  • COVID-19 frequently causes kidney damage, with AKI being a significant predictor of mortality.
  • Pathological findings suggest direct SARS-CoV-2 infection of renal cells and acute tubular necrosis.
  • Other contributing factors may include rhabdomyolysis and glomerulopathies.

Conclusions:

  • AKI is a serious complication of COVID-19 with unclear pathophysiology.
  • Further research into antiviral and anti-inflammatory treatments is ongoing.
  • Organ-protective strategies are essential for managing kidney health during the pandemic.

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