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Updated: Nov 21, 2025

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
Published on: December 1, 2023
rfaRm: An R client-side interface to facilitate the analysis of the Rfam database of RNA families
Lara Sellés Vidal1, Rafael Ayala2, Guy-Bart Stan1
1Department of Bioengineering, Faculty of Engineering, Imperial College London, London, United Kingdom.
Abstract:
rfaRm is an R package providing a client-side interface for the Rfam database of non-coding RNA and other structured RNA elements. The package facilitates the search of the Rfam database by keywords or sequences, as well as the retrieval of all available information about specific Rfam families, such as member sequences, multiple sequence alignments, secondary structures and covariance models. By providing such programmatic access to the Rfam database, rfaRm enables genomic workflows to incorporate information about non-coding RNA, whose potential cannot be fully exploited just through interactive access to the database. The features of rfaRm are demonstrated by using it to analyze the SARS-CoV-2 genome as an example case.
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