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Updated: Nov 21, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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Published on: March 2, 2014

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Role of p38 mitogen-activated protein kinase signalling in virus replication and potential for developing broad

Yogesh Chander1,2, Ram Kumar1,3, Nitin Khandelwal1,4

  • 1National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, Haryana, India.

Reviews in Medical Virology
|January 15, 2021
PubMed

Insights

This review explores how the p38 mitogen-activated protein kinase (MAPK) pathway is involved in viral infections and cellular defense mechanisms. Targeting this pathway offers a promising strategy for developing broad-spectrum antiviral drugs.

Area of Science:

  • Cellular Biology
  • Virology
  • Pharmacology

Background:

  • Mitogen-activated protein kinases (MAPKs) are crucial for cellular processes like proliferation and apoptosis.
  • The p38 MAPK pathway is activated by cellular stress and regulates critical functions including inflammation and antiviral responses.
  • Viruses can manipulate host cell signaling pathways, including p38 MAPK, to facilitate their replication.

Purpose of the Study:

  • To review the role of the p38 signaling pathway in viral infections.
  • To explore the potential of targeting p38 MAPK for antiviral drug development.
  • To identify strategies for developing broad-spectrum antiviral agents.

Main Methods:

  • Literature review of cellular and viral events regulated by the p38 signaling pathway.
  • Analysis of the p38 MAPK's involvement in host-pathogen interactions.
  • Examination of small molecule inhibitors targeting kinase activity.

Main Results:

  • The p38 MAPK pathway plays a dual role in viral infections, acting in both cellular defense and viral replication.
  • Dysregulation of p38 signaling by viruses can be exploited for therapeutic intervention.
  • Targeting cellular signaling pathways presents a viable strategy for broad-spectrum antiviral drug discovery.

Conclusions:

  • The p38 signaling pathway is a significant target for antiviral drug development.
  • Inhibiting specific p38-mediated events could lead to novel antiviral therapies.
  • Further research into p38 MAPK modulation may yield broad-spectrum antiviral candidates.
Keywords:
MAPKp38signalling pathwayvirus infection

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